Defects in the bilirubin conjugation and excretion pathways within hepatocytes result in hyperbilirubinemia.
- Hyperbilirubinemia is characterized by serum bilirubin levels of ≥ 1.1 mg/dL.
- Syndromes associated with hyperbilirubinemia lead to isolated hyperbilirubinemia and hence do not affect liver enzymes.
Red indicators link hereditary hyperbilirubinemias with corresponding dysfunctional enzymes and transporters.
Indirect Hyperbilirubinemia
Gilbert Syndrome
Crigler-Najjar Syndrome
Direct Hyperbilirubinemia
Rotor Syndrome
Dubin-Johnson Syndrome